Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus
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چکیده
منابع مشابه
Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus
Epigenetic processes are primary candidates when searching for mechanisms that can stably modulate gene expression and metabolic pathways according to early life conditions. To test the effects of gestational diabetes mellitus (GDM) on the epigenome of the next generation, cord blood and placenta tissue were obtained from 88 newborns of mothers with dietetically treated GDM, 98 with insulin-dep...
متن کاملEpigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus.
It is now well accepted that offspring exposed to maternal undernutrition, obesity, or gestational diabetes mellitus have an increased risk for chronic diseases later in life, supporting the theory of the early origins of chronic diseases. However, the molecular mechanisms through which the exposure to an altered in utero environment translates into the development of chronic diseases are not y...
متن کاملGestational diabetes mellitus
Introduction: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The prevalence range from 1 to 14% of all pregnancies, depending on the population studied and the diagnostic tests employed. Risk assessment for GDM should be undertaken at the prenatal visit. Women with clinical characteristics of GDM should und...
متن کاملFetal programming and gestational diabetes mellitus.
Gestational diabetes mellitus is defined by new-onset glucose intolerance during pregnancy. About 2-5% of all pregnant women develop gestational diabetes during their pregnancies and the prevalence has increased considerably during the last decade. This metabolic condition is manifested when pancreatic β-cells lose their ability to compensate for increased insulin resistance during pregnancy, h...
متن کاملLeptin DNA methylation in gestational diabetes
This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in pr...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2012
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-0289